We are pleased to announce the release of the inaugural issue of the BETTER Life E-Zine: May, 2023 Issue #1. This publication provides a detailed look into our mission and objectives, delivering crucial information on topics ranging from the strategic planning and governance of the EU BETTER Life Centre to a well-defined framework for Socially Engaged Research (SER) in life sciences. We also delve into our consultation events with Quadruple Helix actors and provide a sneak peek into our co-organised summer school, “Engaging Science for Better Cities”. Take this opportunity to learn more about the needs, capacities, and challenges of regional ecosystems and join us on our journey towards a better life for all. Explore May, 2023 Issue #1 to embark on this journey with us.